2-hydroxy-6-[(8Z-11Z)-pentadeca-8-11-14-trien-1-yl]benzoic-acid and Inflammation

2-hydroxy-6-[(8Z-11Z)-pentadeca-8-11-14-trien-1-yl]benzoic-acid has been researched along with Inflammation* in 1 studies

Other Studies

1 other study(ies) available for 2-hydroxy-6-[(8Z-11Z)-pentadeca-8-11-14-trien-1-yl]benzoic-acid and Inflammation

ArticleYear
Improved inhibition of the histone acetyltransferase PCAF by an anacardic acid derivative.
    Bioorganic & medicinal chemistry, 2010, Aug-15, Volume: 18, Issue:16

    Several lines of evidence indicate that histone acetyltransferases (HATs) are novel drug targets for treatment of diseases like, for example, cancer and inflammation. The natural product anacardic acid is a starting point for development of small molecule inhibitors of the histone acetyltransferase (HAT) p300/CBP associated factor (PCAF). In order to optimize the inhibitory potency, a binding model for PCAF inhibition by anacardic acid was proposed and new anacardic acid derivatives were designed. Ten new derivatives were synthesized using a novel synthetic route. One compound showed a twofold improved inhibitory potency for the PCAF HAT activity and a twofold improved inhibition of histone acetylation in HEP G2 cells.

    Topics: Anacardic Acids; Enzyme Inhibitors; Hep G2 Cells; Histone Acetyltransferases; Humans; Inflammation; Models, Molecular

2010